Illuminations on the Danube with 2 Nights in Prague (Eastbound)

Arles, the most important city in Roman Gaul after Lyon, wears its history with casual magnificence: a first-century amphitheatre still hosts bullfights beneath open skies, and the haunting Alyscamps necropolis — once among the most prestigious burial grounds in the Western world — lines a poplar-shaded avenue with ancient sarcophagi. Yet Arles is equally celebrated as the city that intoxicated Vincent van Gogh, who produced over three hundred works here in fifteen fevered months; the Fondation Vincent van Gogh now honors his legacy in beautifully renovated rooms. Spring and autumn are ideal, with the Camargue's flamingo-filled wetlands just minutes south. Lyon is two hours north by TGV.

Sitting directly across the Rhine from Strasbourg, Kehl offers Rhine river cruise guests the remarkable experience of crossing from Germany into France in five minutes on foot — arriving at a medieval Alsatian cathedral quarter whose tarte flambée, Riesling estates, and half-timbered Petite France canals represent some of Europe's most enduring pleasures. The surrounding Black Forest and Alsatian Wine Route extend the discovery. Spring blossoms and autumn harvest are the most atmospheric times to visit this Franco-German frontier town.

Avignon's Palais des Papes — a fortress-palace of staggering medieval ambition where seven successive popes held court for seventy years — still dominates this Provençal city's skyline, its limestone bulk enclosing frescoed chapels and vast ceremonial halls that once shaped the destiny of Christendom. In July, the city transforms for the celebrated Festival d'Avignon, Europe's premier theatre gathering, turning every courtyard and cloister into a stage. Year-round, the beautifully preserved historic centre offers world-class Rhône Valley wines, refined Provençal cuisine, and the beguiling spectacle of the Pont Saint-Bénézet stretching halfway across the river. Lyon and Marseille are each accessible in under ninety minutes by TGV.

Viviers is one of France's most beautifully preserved medieval secrets — a cathedral town of barely four thousand souls perched on a limestone spur above the Rhône, serving as an episcopal seat since the fifth century when its bishops chose this formidable rock over the declining Roman city below. The Romanesque bell tower, vaulted passageways, and Renaissance townhouses of the haute ville form an ensemble of extraordinary architectural coherence, virtually unaltered since the seventeenth century. River cruise guests arriving from Lyon or Avignon typically spend languid afternoons exploring these narrow, time-suspended streets, best visited in spring or early autumn when Rhône Valley light is at its most golden.

Crowned by a Vauban citadel that UNESCO recognises as one of Europe's finest military fortifications, Blaye guards the Gironde estuary with a watchful grandeur unchanged since Louis XIV's engineers completed their work in 1689. Taste the local delicacy of poutargue de Blaye — cured mullet roe from the estuary — explore the merlot vineyards of the Blaye Côtes de Bordeaux appellation, and take an excursion south to Bordeaux's grand neoclassical boulevards. September and October bring the heady aromas of harvest season to the surrounding wine country.

Tain-l'Hermitage is the beating heart of the northern Rhône wine country, a compact town whose steeply terraced granite hill has yielded some of France's most majestic Syrahs and finest Marsannes since the Roman era. The revered Hermitage hill — its legend entwined with a thirteenth-century crusader hermit — rises directly behind the main street, and the great wine estates of Jaboulet, Chapoutier, and Ferraton offer some of the Loire Valley's most memorable cellar tastings. Autumn harvest season brings the vineyards to their most photogenic golden glory; spring and summer offer ideal touring weather along the Rhône cycling routes between vines and river.

Melk Abbey is among the most theatrical expressions of Baroque ambition in all of Europe — a gilded monastery perched on a granite outcrop above the Danube, its domed church and frescoed library presiding over the Wachau Valley with serene authority since Benedictine monks replaced the Babenberg fortress in 1089. Umberto Eco immortalised it as the inspiration for his labyrinthine monastery in "The Name of the Rose," and the library's 100,000 medieval manuscripts remain one of the continent's supreme collections. After the abbey, stroll down to the historic market town and sample the valley's celebrated Grüner Veltliner wines. The Wachau is at its most bewitching in April and October.

Lyon sits at the confluence of the Rhône and the Saône — a geographic destiny that made it the capital of Roman Gaul, a Renaissance silk-trading powerhouse, and, by contemporary consensus, the undisputed gastronomic capital of France. The UNESCO-listed Vieux Lyon preserves Europe's finest concentration of Renaissance architecture, its labyrinthine traboules — secret passageways threading through courtyard after courtyard — offering endless discovery. Paul Bocuse's legacy lives on in the city's constellation of bouchons, where quenelles de brochet and tablier de sapeur are served with the straightforward confidence of a city that has never needed to prove its culinary supremacy. Lyon rewards a visit in any season, with the Festival of Lights in December being particularly magical.

Krems an der Donau has stood at the eastern gateway of the Wachau Valley — Austria's most beautiful stretch of the Danube — since Emperor Otto III granted it market rights in 995 AD, making it one of the country's oldest documented towns. The UNESCO-listed Wachau landscape surrounding the city is a masterpiece of vineyard terraces, Baroque abbeys, and medieval castles reflected in the river; the Grüner Veltliner and Riesling wines produced here are among Austria's finest. Must-dos include visiting the monumental Melk Abbey and cycling the Danube Cycle Path through the valley. Krems is most enchanting April through October, with the harvest season in September offering wine cellar tastings of exceptional depth.

Tournus is a captivating commune in eastern France, renowned for its rich history, stunning architecture, and exceptional culinary experiences. Must-do activities include exploring the Abbey of Saint-Philibert and indulging in local dishes like coq au vin. The best season to visit is spring or early autumn when the weather is mild and the local markets are brimming with fresh produce.

Birthplace of photography and gateway to Burgundy's finest vineyards, Chalon-sur-Saône is a Saône River gem that rewards those who linger beyond its famous streets. The Musée Nicéphore Niépce, housed in a riverside mansion, chronicles the invention of the medium that changed human perception forever, while the surrounding Côte Chalonnaise wine villages — Mercurey, Givry, Rully — offer some of Burgundy's most approachable yet complex Pinot Noirs. Visit in late summer or early autumn for harvest season, when the vineyards blush gold and local restaurants celebrate the new vintage.

Vernon is a quietly beguiling Norman town on the Seine whose greatest treasure lies just four kilometers beyond its medieval bridge: the garden and water lily ponds at Giverny, where Claude Monet lived and painted for forty-three years, creating the luminous imagery that changed the course of modern art. The town itself retains considerable charm — a romanticly ruined twelfth-century bridge tower draped in ivy, half-timbered houses along the riverbank, and a fine museum housing several original Monet canvases. Monet's garden is open from April through October, reaching its peak splendor in May and June when his beloved water lilies are in full, painterly bloom.

Caudebec-en-Caux nestles in a Seine meander between Rouen and the sea, famous for its Flamboyant Gothic Eglise Notre-Dame — a masterwork of late medieval stone lacework so exquisite that Henri IV called it 'the most beautiful chapel in my kingdom.' The town serves as an ideal quiet base for exploring the Seine Valley's quieter pleasures: the remarkable Abbaye de Jumiéges, its roofless nave open to the Norman sky, and the Manoir d'Ango, a Renaissance manor of extraordinary ambition, are both within easy reach. The tidal atmosphere of the Seine at this point rewards early morning walks along the embankment. Rouen, with its Gothic cathedral and Impressionist legacy, lies forty minutes east.

Visegrád commands the Danube’s most dramatic bend from a hilltop citadel that once housed the Hungarian Crown Jewels and a Renaissance royal palace rivaling Italian courts. Must-dos include climbing to the Upper Castle for panoramic Danube Bend views, exploring King Matthias’s restored palace and Hercules Fountain, and tasting Hungarian gulyás with Etyek wines. Visit April through October, with autumn foliage adding golden drama to the sweeping river views.