Aegean Voyage: Istanbul to Athens - Southbound

For more than fifteen centuries, Istanbul has been the pivot upon which empires turned — Byzantium, Constantinople, the Ottoman capital — and nowhere else on earth compresses so much history into a single horizon. The Hagia Sophia, the Blue Mosque, and the Topkapi Palace form an incomparable trinity of architectural genius along the Golden Horn; the Grand Bazaar's four thousand shops offer a sensory immersion unlike any other marketplace. Must-dos include a Bosphorus sunset cruise and a meal of mezze along the waterfront at Karaköy. Spring (April–May) and autumn (September–October) offer the most gracious climate for this inexhaustible city.

The Hippodrome is the ancient chariot-racing arena of Constantinople, now an open square in Istanbul's Sultanahmet district preserving Egyptian obelisks and Greek bronze monuments amid layers of Byzantine and Ottoman history. Must-dos include examining the 3,500-year-old Obelisk of Theodosius, visiting the adjacent Blue Mosque and Hagia Sophia, and contemplating the site of the Nika Revolt. Visit in spring or autumn for comfortable temperatures and atmospheric light.

For more than fifteen centuries, Istanbul has been the pivot upon which empires turned — Byzantium, Constantinople, the Ottoman capital — and nowhere else on earth compresses so much history into a single horizon. The Hagia Sophia, the Blue Mosque, and the Topkapi Palace form an incomparable trinity of architectural genius along the Golden Horn; the Grand Bazaar's four thousand shops offer a sensory immersion unlike any other marketplace. Must-dos include a Bosphorus sunset cruise and a meal of mezze along the waterfront at Karaköy. Spring (April–May) and autumn (September–October) offer the most gracious climate for this inexhaustible city.

Lemnos is a windswept Aegean island rich in mythology and history, home to possibly Europe's oldest city at Poliochni, the staging harbour for Gallipoli at Mudros, and outstanding local wines and cheeses largely unknown beyond Greece. Must-do experiences include exploring the Bronze Age ruins, tasting Muscat wine and melichloro cheese, and windsurfing in the reliable meltemi. May through October offers the best conditions, with peak winds in July-August.

Mykonos is the Aegean at its most seductive — a labyrinth of bougainvillea-draped whitewashed alleys designed to disorient pirates (and occasionally visitors) leading to Kástro, the medieval hilltop quarter overlooking Little Venice, where balconied houses hang directly above the sea. The island's famous windmills, perched on a ridge above the old harbour, are best photographed at golden hour as pelicans patrol the waterfront below. Visit the sacred archaeological island of Delos — a 30-minute boat crossing — for one of the most significant ancient sites in the Greek world. May, June, and September offer the perfect balance of warmth, light, and bearable crowds.

Kuşadası owes its place on the world's cruise itineraries to one extraordinary proximity: the ancient city of Ephesus, one of the greatest metropolises of the Greco-Roman world, lies just seventeen kilometres from the port. Ephesus — with its two-kilometre marble colonnade, the Library of Celsus, and the Temple of Artemis (one of the Seven Wonders of the Ancient World) — demands at least half a day of unhurried exploration. The House of the Virgin Mary, a pilgrimage site believed to be where Mary spent her final years, adds a profound spiritual dimension. Kuşadası itself is a lively Aegean resort; the season runs April through October, with May and September offering ideal temperatures and smaller crowds.

Bodrum is the site of ancient Halicarnassus and one of the Seven Wonders, now a whitewashed Aegean resort town where the Knights Hospitaller castle houses the world's finest underwater archaeology museum. Visit June or September via Explora Journeys or Virgin Voyages for peninsula village dining, Bronze Age shipwreck treasures, and Turkey's most seductive balance of ancient heritage and contemporary Mediterranean sophistication.

Santorini, the ancient volcanic caldera rising from the Aegean, is Greece's most theatrical landscape — a crescentic island of sheer white cliffs plunging into an indigo sea, its clifftop villages of Fira and Oia draped in bougainvillea and culminating in the world's most photographed sunset. The island's unique Assyrtiko wine, grown on ancient ungrafted vines in volcanic pumice, is one of the Mediterranean's greatest expressions of terroir. Byzantine frescoes of extraordinary beauty fill the Prehistoric Museum of Thera. The volcanic black and red sand beaches of Perissa and Perivolos are unlike any others in Greece. April through June and September through October offer the finest conditions.