Rome (Civitavecchia) to Athens

Rome's ancient maritime gateway since the Emperor Trajan commissioned its harbour in 106 AD, Civitavecchia is the natural prologue to the Eternal City — just seventy minutes southeast by express rail. The port's Renaissance fortress, designed in part by Michelangelo, anchors a working waterfront that has welcomed travellers for millennia. Beyond Rome's unmissable monuments, consider an afternoon in the Civitavecchia thermal baths, drawing on mineral waters prized since antiquity. Spring and autumn offer the ideal balance of mild weather and manageable crowds for exploring the capital's layered history.

Salerno is a historic Campanian port city nestled between the Amalfi Coast and Cilento National Park, home to Europe's first medieval medical school and a magnificent Romanesque cathedral with Byzantine bronze doors. Visitors should not miss the Lungomare Trieste promenade at sunset and a plate of hand-rolled scialatielli ai frutti di mare in the atmospheric old town. The mild Mediterranean climate makes Salerno enchanting year-round, though late spring through early autumn offers the most luminous light and the fullest expression of its coastal character.

Messina guards the storied strait that separates Sicily from the Italian mainland — the passage Homer mythologised as Scylla and Charybdis — and its Norman cathedral's astronomical clock, one of the world's largest mechanical clocks, puts on a captivating automated display each noon as gilded figures enact scenes of the Resurrection. The city was catastrophically rebuilt after the 1908 earthquake, but its markets and waterfront convey the fierce energy of a Sicilian port that has witnessed two and a half millennia of Mediterranean history. Messina is the perfect gateway to Taormina, a 40-minute drive into the hills above the Ionian coast, with views of Etna at their most dramatic. Spring and autumn are ideal.

The port of Kotor, a UNESCO World Heritage site, is renowned for its stunning natural beauty and rich historical tapestry. A must-do experience includes wandering the cobblestone streets of the Old Town, where culinary delights like "kacamak" and fresh seafood await. The best time to visit is during the spring or early fall, when the weather is pleasant and the crowds are fewer.

Dubrovnik, Croatia's stunning port city, is a blend of rich history, dramatic architecture, and vibrant culture, making it a must-visit destination. Don't miss a stroll along the city walls for breathtaking views and savor local dishes like "peka" and "black risotto." The best time to visit is in late spring or early fall when the weather is pleasant and the crowds are thinner.

Rijeka is Croatia's vibrant third city and 2020 European Capital of Culture, where Habsburg waterfront architecture, a thriving arts scene, and one of Europe's most exuberant carnivals create an authentic alternative to the Dalmatian tourist trail. Visit from April through October for the magnificent Korzo promenade, Trsat Castle views, and gateway access to the Kvarner islands.

Venice, approached from the Fusina port across its luminous lagoon, remains one of the world's most extraordinary cities — a thousand-year-old republic built on 118 islands and laced with canals, palaces, and masterpieces. Must-dos include riding the Grand Canal by vaporetto, savouring cicchetti at a traditional bacaro, and visiting the colourful islands of Murano and Burano. April through June and September through November offer the finest light and the most manageable crowds.

Zadar, a historic port city on Croatia's Dalmatian coast, is a captivating blend of ancient architecture and vibrant culture. Must-do experiences include visiting the Church of St. Donatus and enjoying the enchanting music of the Sea Organ. The best season to visit is during the warm summer months when the city comes alive with festivals and outdoor activities.

Bari, Puglia's ancient capital on the Adriatic, has served as a bridge between Western Europe and the Eastern Mediterranean for over two millennia — a heritage visible in the magnificent Basilica di San Nicola, one of medieval Christendom's most important pilgrimage churches, and in the labyrinthine Bari Vecchia where elderly women still hand-roll orecchiette in the street. The surrounding region of Puglia is among Italy's most compelling culinary destinations: burrata born in Andria, focaccia barese, and the puglian cuisine that has recently attracted international attention as Rome's and Florence's quieter, more authentic cousin. Visit April through June and September through October; the Trulli of Alberobello are forty minutes south.

Argostoli is the capital of Kefalonia, the largest Ionian Island, renowned for dramatic geological wonders, pristine beaches, and the literary fame of Captain Corelli's Mandolin. Must-dos include visiting the subterranean Melissani Lake, admiring the cliffs of Myrtos Beach, and tasting Robola wine with fresh-grilled fish. May through October offers warm weather and calm seas, with June and September providing the best balance of conditions.

Monemvasia, a fortified port town on the Peloponnese, is celebrated for its medieval architecture and rich history dating back to the 6th century. Must-do experiences include savoring local dishes like **mpakaliaro** and exploring nearby attractions such as Nydri and Symi. The best time to visit is spring or early autumn when the weather is mild and the crowds are manageable.

Santorini, the ancient volcanic caldera rising from the Aegean, is Greece's most theatrical landscape — a crescentic island of sheer white cliffs plunging into an indigo sea, its clifftop villages of Fira and Oia draped in bougainvillea and culminating in the world's most photographed sunset. The island's unique Assyrtiko wine, grown on ancient ungrafted vines in volcanic pumice, is one of the Mediterranean's greatest expressions of terroir. Byzantine frescoes of extraordinary beauty fill the Prehistoric Museum of Thera. The volcanic black and red sand beaches of Perissa and Perivolos are unlike any others in Greece. April through June and September through October offer the finest conditions.

Mykonos is the Aegean at its most seductive — a labyrinth of bougainvillea-draped whitewashed alleys designed to disorient pirates (and occasionally visitors) leading to Kástro, the medieval hilltop quarter overlooking Little Venice, where balconied houses hang directly above the sea. The island's famous windmills, perched on a ridge above the old harbour, are best photographed at golden hour as pelicans patrol the waterfront below. Visit the sacred archaeological island of Delos — a 30-minute boat crossing — for one of the most significant ancient sites in the Greek world. May, June, and September offer the perfect balance of warmth, light, and bearable crowds.

The port that launched Athenian democracy's naval supremacy at the Battle of Salamis, Piraeus remains Greece's maritime heartbeat — and the most convenient gateway to both the Acropolis and the Aegean island chains. Dine on grilled sea bream at a Mikrolimano harbourside taverna, visit the extraordinary bronze Piraeus Apollo, and set sail for Hydra or Santorini by afternoon. Late April through June and September offer the Aegean at its most golden and uncrowded.