Danube Dreams with 2 Nights in Prague (Eastbound)

Birthplace of photography and gateway to Burgundy's finest vineyards, Chalon-sur-Saône is a Saône River gem that rewards those who linger beyond its famous streets. The Musée Nicéphore Niépce, housed in a riverside mansion, chronicles the invention of the medium that changed human perception forever, while the surrounding Côte Chalonnaise wine villages — Mercurey, Givry, Rully — offer some of Burgundy's most approachable yet complex Pinot Noirs. Visit in late summer or early autumn for harvest season, when the vineyards blush gold and local restaurants celebrate the new vintage.

Tournus is a captivating commune in eastern France, renowned for its rich history, stunning architecture, and exceptional culinary experiences. Must-do activities include exploring the Abbey of Saint-Philibert and indulging in local dishes like coq au vin. The best season to visit is spring or early autumn when the weather is mild and the local markets are brimming with fresh produce.

Lyon sits at the confluence of the Rhône and the Saône — a geographic destiny that made it the capital of Roman Gaul, a Renaissance silk-trading powerhouse, and, by contemporary consensus, the undisputed gastronomic capital of France. The UNESCO-listed Vieux Lyon preserves Europe's finest concentration of Renaissance architecture, its labyrinthine traboules — secret passageways threading through courtyard after courtyard — offering endless discovery. Paul Bocuse's legacy lives on in the city's constellation of bouchons, where quenelles de brochet and tablier de sapeur are served with the straightforward confidence of a city that has never needed to prove its culinary supremacy. Lyon rewards a visit in any season, with the Festival of Lights in December being particularly magical.

Sitting directly across the Rhine from Strasbourg, Kehl offers Rhine river cruise guests the remarkable experience of crossing from Germany into France in five minutes on foot — arriving at a medieval Alsatian cathedral quarter whose tarte flambée, Riesling estates, and half-timbered Petite France canals represent some of Europe's most enduring pleasures. The surrounding Black Forest and Alsatian Wine Route extend the discovery. Spring blossoms and autumn harvest are the most atmospheric times to visit this Franco-German frontier town.

Passau occupies one of Central Europe's most dramatic natural stages — a narrow peninsula at the confluence of three rivers, the Danube, Inn, and Ilz, where the old town's baroque spires and shuttered merchants' houses crowd the very tip of the land between the waters. St. Stephen's Cathedral houses the world's largest church organ, a 17,974-pipe instrument whose daily concerts fill the nave with a sound that seems architectural in its density. The Veste Oberhaus fortress above the city commands panoramic views across three countries on clear days. Passau is a classic Danube river cruise departure point; spring and early autumn, when the river runs high and the light turns golden, are the finest seasons.

Tournon-sur-Rhône is a captivating port town steeped in history, known for its medieval architecture and vibrant culinary scene. Must-do experiences include savoring local specialties such as caillettes and exploring the bustling Saturday market. The best time to visit is in the late spring or early fall when the weather is mild and the local festivities are in full swing.

Avignon's Palais des Papes — a fortress-palace of staggering medieval ambition where seven successive popes held court for seventy years — still dominates this Provençal city's skyline, its limestone bulk enclosing frescoed chapels and vast ceremonial halls that once shaped the destiny of Christendom. In July, the city transforms for the celebrated Festival d'Avignon, Europe's premier theatre gathering, turning every courtyard and cloister into a stage. Year-round, the beautifully preserved historic centre offers world-class Rhône Valley wines, refined Provençal cuisine, and the beguiling spectacle of the Pont Saint-Bénézet stretching halfway across the river. Lyon and Marseille are each accessible in under ninety minutes by TGV.

Dürnstein is the jewel of the Wachau — that UNESCO-protected stretch of the Danube where medieval villages, baroque spires, and precipitous terraced vineyards create the most picturesque river landscape in Central Europe. The blue-and-white tower of the Augustinian monastery and the dramatic ruins of the castle where Richard the Lionheart was imprisoned in 1192 define a skyline of romantic perfection. The surrounding vineyards produce some of Austria's greatest Grüner Veltliners and Rieslings; tasting rooms open directly onto the river path. May through October offers the finest conditions, with harvest season in September an especially memorable time to visit.

Arles, the most important city in Roman Gaul after Lyon, wears its history with casual magnificence: a first-century amphitheatre still hosts bullfights beneath open skies, and the haunting Alyscamps necropolis — once among the most prestigious burial grounds in the Western world — lines a poplar-shaded avenue with ancient sarcophagi. Yet Arles is equally celebrated as the city that intoxicated Vincent van Gogh, who produced over three hundred works here in fifteen fevered months; the Fondation Vincent van Gogh now honors his legacy in beautifully renovated rooms. Spring and autumn are ideal, with the Camargue's flamingo-filled wetlands just minutes south. Lyon is two hours north by TGV.