Romantic Rhine with Swiss Alps, 3 Nights in Lake Como & 1 Night in Lucerne (Northbound)

Arles, the most important city in Roman Gaul after Lyon, wears its history with casual magnificence: a first-century amphitheatre still hosts bullfights beneath open skies, and the haunting Alyscamps necropolis — once among the most prestigious burial grounds in the Western world — lines a poplar-shaded avenue with ancient sarcophagi. Yet Arles is equally celebrated as the city that intoxicated Vincent van Gogh, who produced over three hundred works here in fifteen fevered months; the Fondation Vincent van Gogh now honors his legacy in beautifully renovated rooms. Spring and autumn are ideal, with the Camargue's flamingo-filled wetlands just minutes south. Lyon is two hours north by TGV.

Port-Saint-Louis-du-Rhône marks where France's great river meets the Mediterranean at the edge of the Camargue — Europe's wildest wetland, where white horses, black bulls, and improbable pink flamingos inhabit salt marshes and lagoons. Visit April through June via Avalon Waterways' Rhône itineraries for flamingo breeding season, proximity to Van Gogh's Arles, and the medieval fortress-city of Aigues-Mortes.

Arles, the most important city in Roman Gaul after Lyon, wears its history with casual magnificence: a first-century amphitheatre still hosts bullfights beneath open skies, and the haunting Alyscamps necropolis — once among the most prestigious burial grounds in the Western world — lines a poplar-shaded avenue with ancient sarcophagi. Yet Arles is equally celebrated as the city that intoxicated Vincent van Gogh, who produced over three hundred works here in fifteen fevered months; the Fondation Vincent van Gogh now honors his legacy in beautifully renovated rooms. Spring and autumn are ideal, with the Camargue's flamingo-filled wetlands just minutes south. Lyon is two hours north by TGV.

Avignon's Palais des Papes — a fortress-palace of staggering medieval ambition where seven successive popes held court for seventy years — still dominates this Provençal city's skyline, its limestone bulk enclosing frescoed chapels and vast ceremonial halls that once shaped the destiny of Christendom. In July, the city transforms for the celebrated Festival d'Avignon, Europe's premier theatre gathering, turning every courtyard and cloister into a stage. Year-round, the beautifully preserved historic centre offers world-class Rhône Valley wines, refined Provençal cuisine, and the beguiling spectacle of the Pont Saint-Bénézet stretching halfway across the river. Lyon and Marseille are each accessible in under ninety minutes by TGV.

The port of Ghent, a historic trade hub with medieval architecture, is a vibrant gateway to Belgian culture. Don't miss savoring local dishes like "stoverij" and "waterzooi," or wandering the picturesque canals. The best time to visit is during the summer months, particularly during the lively ‘Gentse Feesten’ festival.

Framed by snowcapped Alps and the mirror-bright waters of Lake Lucerne, this medieval Swiss gem centres on the 14th-century Kapellbrücke — one of Europe's oldest covered bridges — and a colourful Altstadt that has changed little in five centuries. Ride the cog railway to cloud-wreathed Mount Pilatus, savour Älplermagronen in a timber-beamed tavern, and explore the nearby wonders of Interlaken and Grindelwald. Late spring through early autumn offers the most spectacular lake reflections and settled mountain weather.

Viviers is one of France's most beautifully preserved medieval secrets — a cathedral town of barely four thousand souls perched on a limestone spur above the Rhône, serving as an episcopal seat since the fifth century when its bishops chose this formidable rock over the declining Roman city below. The Romanesque bell tower, vaulted passageways, and Renaissance townhouses of the haute ville form an ensemble of extraordinary architectural coherence, virtually unaltered since the seventeenth century. River cruise guests arriving from Lyon or Avignon typically spend languid afternoons exploring these narrow, time-suspended streets, best visited in spring or early autumn when Rhône Valley light is at its most golden.

Basel, where Switzerland, France, and Germany converge at the Rhine's northward bend, hosts a concentration of world-class art institutions that rivals any city its size on earth — the Kunstmuseum alone, the world's oldest public art collection, could occupy days, and Art Basel each June draws every name that matters in the contemporary art world to this compact, elegant city. The Rhine itself is the city's great social artery: in summer, locals jump in with waterproof bags and float downstream, a tradition as charming as any museum. Spring through autumn is ideal for outdoor exploration; Paris is just three hours by TGV and Strasbourg a mere twenty minutes by train.

Tournon-sur-Rhône is a captivating port town steeped in history, known for its medieval architecture and vibrant culinary scene. Must-do experiences include savoring local specialties such as caillettes and exploring the bustling Saturday market. The best time to visit is in the late spring or early fall when the weather is mild and the local festivities are in full swing.

Lyon sits at the confluence of the Rhône and the Saône — a geographic destiny that made it the capital of Roman Gaul, a Renaissance silk-trading powerhouse, and, by contemporary consensus, the undisputed gastronomic capital of France. The UNESCO-listed Vieux Lyon preserves Europe's finest concentration of Renaissance architecture, its labyrinthine traboules — secret passageways threading through courtyard after courtyard — offering endless discovery. Paul Bocuse's legacy lives on in the city's constellation of bouchons, where quenelles de brochet and tablier de sapeur are served with the straightforward confidence of a city that has never needed to prove its culinary supremacy. Lyon rewards a visit in any season, with the Festival of Lights in December being particularly magical.